White Matter Water Content in Multiple Sclerosis and Neuromyelitis Optica
Irene Vavasour1, Sandra Meyers2, Praveena Manogaran3, Shuhan Xiao3, Anika Wurl3, Katrina McMullan3, David Li1, Anthony Traboulsee3, and Shannon Kolind3
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 3Medicine, University of British Columbia, Vancouver, BC, Canada
Multiple sclerosis (MS) and neuromyelitis optica (NMO)
are both autoimmune diseases of the central nervous system. Normal appearing
white matter is known to be affected by diffuse tissue damage in MS whereas
damage in NMO is thought to be restricted to acute lesions. Surprisingly, in
this study, water content within whole white matter and white matter tracts of
subjects with neuromyelitis optica (NMO) was found to be higher than in healthy
matched controls and similar to MS. Both NMO and MS lesions had a higher water
content compared to normal appearing white matter.
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