Abstract #4056

White Matter Water Content in Multiple Sclerosis and Neuromyelitis Optica

Irene Vavasour¹, Sandra Meyers², Praveena Manogaran³, Shuhan Xiao³, Anika Wurl³, Katrina McMullan³, David Li¹, Anthony Traboulsee³, and Shannon Kolind³

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Medicine, University of British Columbia, Vancouver, BC, Canada

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are both autoimmune diseases of the central nervous system. Normal appearing white matter is known to be affected by diffuse tissue damage in MS whereas damage in NMO is thought to be restricted to acute lesions. Surprisingly, in this study, water content within whole white matter and white matter tracts of subjects with neuromyelitis optica (NMO) was found to be higher than in healthy matched controls and similar to MS. Both NMO and MS lesions had a higher water content compared to normal appearing white matter.

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