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Abstract #4057

A randomized controlled trial on the efficacy of cognitive training in MS reveals functional connectivity changes

Ottavia Dipasquale1,2, Jamie Campbell3, Camila Callegari Piccinin4, Dawn Langdon5, Waqar Rashid6, and Mara Cercignani3

1IRCCS, Don Gnocchi Foundation, Milan, Italy, 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, 3Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 4Neuroimaging Laboratory, University of Campinas, Cidade Universitária, Campinas, Brazil, 5Psychology Department, Royal Holloway, University of London, Egham, United Kingdom, 6Department of Neurology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom

We investigated the resting-state functional connectivity (FC) changes induced after 6 weeks of computerised, home-based cognitive rehabilitation in patients with multiple sclerosis (MS) in a randomized controlled trial. The intervention and control groups were evaluated at baseline (T1), after a 6-week intervention period (T2) and a 12-week follow-up period (T3). Out of the 94 regions investigated, many memory-, attention- and motor-related areas strengthened their FC at T2 and T3 in the intervention group. This study supports the hypothesis that this cognitive rehabilitation is a feasible and effective approach in patients with MS and confirms that rfMRI is a useful tool for mapping plastic changes.

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