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Abstract #4063

Assessment of grey matter cortical lesions in Multiple Sclerosis using high resolution ASL at 7T

Richard J Dury1, Molly G Bright1, Yasser Falah2, Penny A Gowland1, Nikos Evangelou2, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Nottingham University Hospital, University of Nottingham, Nottingham, United Kingdom

Grey matter cortical lesions have been associated with physical disability, cognitive impairment and fatigue in Multiple Sclerosis. Only one previous study has assessed cerebral blood flow (CBF) and cerebral blood volume (CBV) within cortical lesions. Here we use high spatial resolution 7T FAIR TrueFISP ASL to assess the perfusion in grey matter cortical lesions and compare this to surrounding normal appearing grey matter. Cortical lesions showed a significant 32% reduction in perfusion signal compared to normal appearing grey matter. This ASL method can be used to evaluate longitudinal perfusion changes in new and chronic cortical lesions.

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