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Abstract #4064

Energy dysregulation and neuro-axonal dysfunction in multiple sclerosis measured in-vivo with diffusion-weighted spectroscopy

Benedetta Bodini1, Francesca Branzoli1,2, Emilie Poirion1, Daniel Garcia-Lorenzo1,2, Elisabeth Maillart1, Julie Socha1, Geraldine Bera1, Itamar Ronen3, Stephane Lehericy1,2, and Bruno Stankoff1

1Brain and Spine Institute, INSERM U1127, Sorbonne Universités, UPMC, CHU Pitié-Salpêtrière, Paris, France, 2Brain and Spine Institute, Center for Neuroimaging Research (CENIR), CHU Pitié-Salpêtrière, Paris, France, 3C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands

Diffusion-weighted spectroscopy (DWS), allowing to measure in-vivo the diffusion properties of endogenous intracellular metabolites such as total N-acetyl-aspartate (tNAA) and total creatine (tCr), offers the opportunity to explore the early phase of neuronal structural damage and energetic mismatch in multiple sclerosis (MS). We compared the apparent diffusion coefficient (ADC) of tNAA and tCr in 25 patients with MS and 20 healthy volunteers, and found a reduced diffusivity of both metabolites in patients, both in the corona radiate and in the thalami. These results may reflect an ongoing neuro-axonal damage and a simultaneous energy dysregulation affecting neurons and/or glial cells in MS.

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