Abstract #4067

2D Localised Correlated Spectroscopy (L-COSY): A potential tool for identifying biochemical changes in Multiple Sclerosis

Jameen ARM¹, Scott Quadrelli², Karen Ribbons³, Jeanette Lechner-Scott³, and Saadallah Ramadan⁴

¹Imaging, HMRI, Newcastle, Australia, ²Imaging, TRI Brisbane, Brisbane, Australia, ³Neurology, John Hunter Hospital, Newcastle, Australia, ⁴Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia

¹H Magnetic Resonance Spectroscopic techniques (1H-MRS) have been utilised to assess inflammatory nature of both acute and chronic lesions as well as normal appearing brain tissue to understand the neuro degenerative irreversible component of multiple sclerosis (MS) from early stages^1-3. However, due to high spectral overlap in one-dimensional (1D) ¹H-MRS, it has been challenging to establish a standard specific spectral pattern in plaques or normal appearing brain tissues. L-COSY might provide the needed spectral dispersion

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