Abstract #4068

Multiple Sclerosis: Assessment of normal-appearing white matter hypoperfusion with DCE MRI

Michael Ingrisch¹, Steven Sourbron², Moritz Schneider¹, Sina Herberich³, Tania Kümpfel⁴, Reinhard Hohlfeld⁴, Maximilian Reiser³, and Birgit Ertl-Wagner³

¹Josef-Lissner-Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany, ²Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ³Institute for Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany, ⁴Institute for Clinical Neuroimmunology, Ludwig-Maximilians-University Munich, Munich, Germany

Several studies have reported diffuse hypoperfusion in normal-appearing white matter(NAWM) in patients with relapsing-remitting multiple sclerosis(RR-MS). Here, we investigate this issue using dynamic contrast-enhanced (DCE)MRI. The statistical power of a DCE-MRI acquisition to reveal hypoperfusion was estimated for n=16 patients at 96% using a Monte-Carlo simulation. 24 patients with RR-MS and 16 healthy controls underwent a DCE-MRI examination and cerebral blood flow (CBF), cerebral blood volume (CBV) and permeability-surface area product (PS) were quantified in NAWM, revealing no significant differences between groups. This indicates that, in our patient cohort, NAWM hypoperfusion is much less pronounced than in previous DSC studies.

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