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Abstract #4068

Multiple Sclerosis: Assessment of normal-appearing white matter hypoperfusion with DCE MRI

Michael Ingrisch1, Steven Sourbron2, Moritz Schneider1, Sina Herberich3, Tania Kümpfel4, Reinhard Hohlfeld4, Maximilian Reiser3, and Birgit Ertl-Wagner3

1Josef-Lissner-Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany, 2Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 3Institute for Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany, 4Institute for Clinical Neuroimmunology, Ludwig-Maximilians-University Munich, Munich, Germany

Several studies have reported diffuse hypoperfusion in normal-appearing white matter(NAWM) in patients with relapsing-remitting multiple sclerosis(RR-MS). Here, we investigate this issue using dynamic contrast-enhanced (DCE)MRI. The statistical power of a DCE-MRI acquisition to reveal hypoperfusion was estimated for n=16 patients at 96% using a Monte-Carlo simulation. 24 patients with RR-MS and 16 healthy controls underwent a DCE-MRI examination and cerebral blood flow (CBF), cerebral blood volume (CBV) and permeability-surface area product (PS) were quantified in NAWM, revealing no significant differences between groups. This indicates that, in our patient cohort, NAWM hypoperfusion is much less pronounced than in previous DSC studies.

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