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Abstract #4070

Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple Sclerosis

Anagha Deshmane1, Kunio Nakamura2, Deepti K Guruprakash2, Yun Jiang 1, Dan Ma3, Jar-Chi Lee 4, Elizabeth Fisher 5, Richard A. Rudick 5, Jeffrey A. Cohen6, Mark J. Lowe6, Daniel Ontaneda6, Mark A. Griswold1,3, and Vikas Gulani1,7

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 3Radiology, Case Western Reserve University, Cleveland, OH, United States, 4Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States, 5Biogen, Boston, MA, United States, 6Mellen Center for Multiple Sclerosis Research and Treatment, Cleveland Clinic, Cleveland, OH, United States, 7Radiology, University Hospitals, Cleveland, OH, United States

Magnetic Resonance Fingerprinting (MRF) is used to simultaneously map T1, T2, and spin density in the normal appearing white matter and normal appearing grey matter of multiple sclerosis patients and healthy controls. Relaxation parameters measured by MRF are found to be significantly different between MS subjects and healthy controls, to distinguish between relapsing remitting MS and secondary progressive MS in certain brain structures, and to correlate with clinical measures of function and disability.

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