Abstract #4071

QSM is sensitive to myelin changes just beyond the boundaries of conventional T2 lesion detection

Sneha Pandya¹, Yan Zhang¹, Thanh Nguyen¹, Yi Wang¹, Susan A Gauthier², and Sneha Pandya¹

¹Department of Radiology, Weill Cornell Medicine, New York, NY, United States, ²Department of Neurology, Weill Cornell Medicine, New York, NY, United States

MRI-derived measures of lesion accrual and tissue loss have acquired a central role in the understanding of MS disease evolution, pathogenesis of symptoms, and prediction of clinical outcome. Conventional MRI imaging is highly sensitive for detection of MS lesions, which are characteristically hyperintense on a T2 weighted images, however this technique lacks pathological specificity. QSM can help identify myelin and iron content changes during an MS lesion’s lifetime.

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