Abstract #4074

Multimodal Characterization of Grey Matter Alterations in Neuromyelitis Optica

Yaou Liu¹, Yunyun Duan², Huiqing Dong², Tianyi Qian², Frederik Barkhof³, Jinhui Wang⁴, and Kuncheng Li²

¹Xuanwu Hospital,Capital Medical University, Beijing, China, People's Republic of, ²Beijing, China, People's Republic of, ³Amsterdam, Netherlands, ⁴Hanzhou, China, People's Republic of

Combining double-inversion-recovery (DIR), high-resolution structural MRI, diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI), this study systematically investigated structural and functional alterations in grey-matter (GM) structures in thirty-five neuromyelitis optica (NMO) patients compared with healthy controls. We demonstrated that NMO exhibits both structural and functional alterations of GM in the cerebrum and cerebellum. Multimodal MRI techniques complementary worked to capture NMO-related GM abnormalities. GM alterations, especially diffusion abnormalities, correlated with cognitive impairment in NMO. These findings have important implications for understanding the roles of GM damage and also for highlighting multimodal MRI techniques as objective biomarkers in NMO.

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