Abstract #4075

A longitudinal assessment of brain iron using quantitative susceptibility mapping (QSM) in multiple sclerosis (MS) over 2 years

Ferdinand Schweser^1,2, Nicola Bertolino¹, Michael G Dwyer¹, Jesper Hagemeier¹, Paul Polak¹, Niels P Bergsland^1,3, Andreas Deistung⁴, Bianca Weinstock-Guttman⁵, Jürgen R Reichenbach^4,6, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ³MR Research Laboratory, IRCCS Don Gnocchi Foundation ONLUS, Milan, Italy, ⁴Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ⁵Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ⁶Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany

Quantitative susceptibility mapping (QSM) is the most sensitive technique currently available to study brain iron in vivo. The technique opens the door to a longitudinal assessment of brain iron, bearing the potential to understand and disentangle factors resulting in the large scatter of reported iron concentrations in later decades of life.

In the present work, we investigated longitudinal changes of brain magnetic susceptibility in a cohort of 40 healthy controls (HCs) and 160 multiple sclerosis (MS) patients over a period of 2 years.

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