Abstract #4076

LONG TERM EFFECTS OF SINGLE VS. REPEATED LOW INTENSITY PULSED FOCUSED ULTRASOUND TREATMENT WITH MICROBUBBLES

Zsofia I. Kovacs¹, Tsang-Wei Tu¹, Georgios Z. Papadakis^1,2, William C. Reid², Dima A. Hammoud², and Joseph A. Frank^1,3

¹Frank Laboratory, Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ²Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ³National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States

One potential issue for using MR-guided pulsed Focused Ultrasound (pFUS) to open the blood brain barrier (BBB) is the lack of data on the long term effects. Safety determination in the brain have been limited to the MR characterization after repeated BBB opening that can be achieved without hemorrhage, edema and behavioral changes in non-human primates (Arvanitis, et al. 2015; Downs, et al. 2015). We use multimodal imaging technics to characterize long term effects of pFUS + MB in the rat brain.

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