Abstract #4080

Morphometric analysis of cerebrospinal fluid alterations by MRI for spontaneous intracranial hypotension patients before and after treatments

Hui-Feng Ho^1,2, Hung-Chieh Chen², Hsin Tung³, Yi-Hsin Tsai⁴, Yi-Ying Wu², Jyh-Wen Chai^2,4, Clayton Chi-Chang Chen², Shin-Lei Peng¹, Wu-Chung Shen¹, and Tzu-Ching Shih¹

¹Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ²Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, ³Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ⁴College of Medicine, China Medical University, Taichung, Taiwan

Cerebrospinal fluid (CSF) is the fluid circulating through the subarachnoid space and providing a neuroprotective function as a hydraulic cushion for the brain and the spinal cord. CSF not only plays a vital role for normal brain function, but also servers numerous important functions in the central nervous system. However, CSF leaks are a key cause of new-onset headaches. Despite numerous reports characterizing CSF and its circulation in subarachnoid space, our understanding of CSF leakage remains limited. In this study, we calculate the CSF volumes in the brain and the spine of SIH patients using T2-weighted MRI images.

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