Abstract #4081

Magnetic resonance spectroscopy reveals oral lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

Rafal Janik¹, Lynsie A.M. Thomason², and Greg J. Stanisz^1,2,3

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Nerurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

We previously have demonstrated that administration of Lactobacillus rhamnosus (JB-1) to healthy male BALB/c mice, promotes consistent changes in GABA-A and -B receptor subtypes in specific brain regions, accompanied by reductions in anxiety and depression-related behaviours. In the present study, using magnetic resonance spectroscopy (MRS), we quantitatively assessed two clinically validated biomarkers of brain activity and function, glutamate + glutamine (Glx) and total N-acetyl aspartate + N-acetylaspartylglutamic acid (tNAA), as well as GABA, the chief brain inhibitory neurotransmitter.

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