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Abstract #4081

Magnetic resonance spectroscopy reveals oral lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

Rafal Janik1, Lynsie A.M. Thomason2, and Greg J. Stanisz1,2,3

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Nerurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

We previously have demonstrated that administration of Lactobacillus rhamnosus (JB-1) to healthy male BALB/c mice, promotes consistent changes in GABA-A and -B receptor subtypes in specific brain regions, accompanied by reductions in anxiety and depression-related behaviours. In the present study, using magnetic resonance spectroscopy (MRS), we quantitatively assessed two clinically validated biomarkers of brain activity and function, glutamate + glutamine (Glx) and total N-acetyl aspartate + N-acetylaspartylglutamic acid (tNAA), as well as GABA, the chief brain inhibitory neurotransmitter.

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