Abstract #4085

Cortical folding patterns in extremely preterm born young adults

Eliza Orasanu¹, Andrew Melbourne¹, Zach Eaton-Rosen¹, David Atkinson², Alexandra Saborowska³, Joanne Beckmann⁴, Neil Marlow⁴, and Sebastien Ourselin¹

¹Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom, ²University College London, London, United Kingdom, ³University College Hospital, London, United Kingdom, ⁴Institute for Women's Health, University College London, London, United Kingdom

Preterm born individuals may be subject to abnormal gyrification, associated with behavioural-cognitive deficit. In this work we perform a cortical folding analysis of the white-grey matter boundary in extremely preterm born young adults when compared to their term born peers, through a groupwise analysis using joint spectral matching. The results show that there are significant differences in folding in the temporal lobe, results which could be connected with poor executive function and language deficits in the extremely preterm cohort.

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