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Abstract #4086

Evaluation of Whole-Body Iron Loading in Transfusion-Dependent Patients with Quantitative Susceptibility Imaging

Zhang Xiaoqi1, Ni Hongyan1, and Qian Tianyi 2

1Tianjin First Central Hospital, Tianjin, China, People's Republic of, 2MR Collaboration NE Asia, Siemens Healthcare, Beijing, China, People's Republic of

To quantify the iron loading in the whole body among transfusion-dependent patients, 32 transfusion-dependent patients and 32 healthy volunteers were recruited to participate in this study. The quantitative susceptibility mapping was processed to get the susceptibility of the ROIs in the brain, and T2*values of their livers, pancreas and myocardium. Significantly higher iron levels in the putamen were found in transfusion-dependent patients (right/left=0.147±0.066/0.149±0.811ppm) compared with healthy controls(right/left=0.064±0.037/0.060±0.326ppm) (P=0.021/0.011). A ROC curve was performed, and the results suggested that liver T2* and pancreas T2* values can be great predictors to diagnose the iron overload in the brain ( AUC=0.877, 0.974, P<0.01).

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