1Tianjin First Central Hospital, Tianjin, China, People's Republic of, 2MR Collaboration NE Asia, Siemens Healthcare, Beijing, China, People's Republic of
To
quantify the iron loading in the whole body among transfusion-dependent
patients, 32 transfusion-dependent patients and 32 healthy volunteers were
recruited to participate in this study. The quantitative susceptibility mapping
was processed to get the susceptibility of the ROIs in the brain, and T2*values
of their livers, pancreas and myocardium. Significantly higher iron levels in
the putamen were found in transfusion-dependent patients
(right/left=0.147±0.066/0.149±0.811ppm) compared with
healthy controls(right/left=0.064±0.037/0.060±0.326ppm) (P=0.021/0.011). A ROC curve was performed, and the results suggested that
liver T2* and pancreas T2* values can be great predictors to diagnose the iron
overload in the brain ( AUC=0.877, 0.974, P＜0.01).
