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Abstract #4088

Quantitative pH using chemical exchange saturation transfer and phosphorous spectroscopy

Zhuozhi Dai1,2, Phillip Zhe Sun3, Gang Xiao4, Gen Yan2, Yanlong Jia2, Zhiwei Shen5, Alan H. Wilman1, and Renhua Wu2,5

1Biomedical engineering, University of Alberta, Edmonton, AB, Canada, 2Medical Imaging, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China, People's Republic of, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH and Harvard Medical School, Charlestown, MA, United States, 4Math and Information Technology, Hanshan Normal University, Chaozhou, China, People's Republic of, 5Provincial key laboratory of medical molecular imaging, Shantou, China, People's Republic of

pH is a very important biochemical property that changes in many pathological states. Monitoring pH is of significance in early diagnosis and treatment therapy. However, there is lack of non-invasive methods to image pH in vivo effectively. Our study quantified the pH value using a chemical exchange saturation transfer (CEST) method in rat brain and established a strong correlation of pH between CEST and 31P-MRS in vivo, Pearson correlation factor is 0.819, P < 0.01. Because CEST imaging has superior spatial resolution to 31P-MRS, CEST may provide an alternative, straightforward, and effective way to obtain quantitative pH images in vivo.

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