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Abstract #4092

Susceptibility Weighted Imaging in the Early Stages of Hypoxia

Sarah C Wayte1, Victoria Sherwood1, Ravjit Sagoo1, Eddie Ng'andwe1, Charles E Hutchinson1,2, and Christopher HE Imray1,2

1University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, 2Warwick Medical School, Warwick University, Coventry, United Kingdom

The apparent changes in venous calibre on susceptibility weighted imaging (SWI) of six normal volunteers pre-hypoxia, during the first 12 minutes of hypoxia, and at 30 and 60 minutes were investigated. For all subjects there was a step increase in apparent venous calibre on SWI which occurred within the first few minutes of hypoxia, and this was maintained up to 60 minutes. The apparent increase in venous calibre occurred too rapidly after hypoxia induction to be entirely due to an increase in vessel volume. The vessels appear dilated because of the greater magnetic susceptibility of deoxyhaemoglobin than oxyhaemoglobin.

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