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Abstract #4093

Imaging of Nicotinamide adenine dinucleotide (NAD+) in vitro using CEST

Puneet Bagga1, Kevin D'Aquilla1, Mohammad Haris2, Hari Hariharan1, and Ravinder Reddy1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar

Nicotinamide adenice dinucleuotide (NAD+) is a ubiquitous molecule present in all cells and tissues of the body with an important role in the redox reactions and metabolism. Small changes in NAD levels may lead to oxidative stress and may be a cause for various disorders. Currently, NAD can be detected in vivo only by 31P NMR spectroscopy. Chemical Exchange Saturation Transfer (CEST) MRI is an imaging technique which exploits the properties of exchangeable protons on the molecule for imaging. In the present study, we have shown the in vitro CEST effect of solution containing NAD+.

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