Puneet Bagga1, Kevin D'Aquilla1, Mohammad Haris2, Hari Hariharan1, and Ravinder Reddy1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar
Nicotinamide adenice dinucleuotide (NAD+) is a ubiquitous molecule
present in all cells and tissues of the body with an important role in the
redox reactions and metabolism. Small changes in NAD levels may lead to
oxidative stress and may be a cause for various disorders. Currently, NAD can
be detected in vivo only by 31P NMR spectroscopy. Chemical Exchange Saturation
Transfer (CEST) MRI is an imaging technique which exploits the properties of
exchangeable protons on the molecule for imaging. In the present study, we have
shown the in vitro CEST effect of solution containing NAD+.
