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Abstract #4094

Frontal-parieto-temporal white matter integrity in chronic HIV infection reflects a complex combination of education level, immune recovery, antiretroviral brain penetration and current neurocognitive functioning

Lucette A Cysique1, James R Soares2, John Geng3, Maia Scarpetta3,4, Bruce J Brew2,5, Roland Henry6, and Caroline D Rae7

1UNSW Australia, NeuRA, Sydney, Australia, 2UNSW Australia, Sydney, Australia, 3NeuRA, Sydney, Australia, 4Reed College, Portland, WA, United States, 5St. Vincent's Hospital, Sydney, Australia, 6UCSF, San Francisco, CA, United States, 7The University of New South Wales, Randwick, Australia

DTI was performed in 40 HIV- men and 82 HIV+ men with comparable demographics and life styles. The study was designed to recruit chronic HIV+ participants with successful viral control. DTI was 32 directions; FA values were quantified in each participant in 12 skeleton regions of interest, which have been associated with HIV-related brain injury. The study present first evidence for complex brain repair processes in treated and chronic HIV infection arguing for careful multilevel characterization of HIV+ samples in neuroHIV DTI studies. The association of neurocognitive function with FA suggests ongoing vulnerability despite successful treatment.

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