Abstract #4094

Frontal-parieto-temporal white matter integrity in chronic HIV infection reflects a complex combination of education level, immune recovery, antiretroviral brain penetration and current neurocognitive functioning

Lucette A Cysique¹, James R Soares², John Geng³, Maia Scarpetta^3,4, Bruce J Brew^2,5, Roland Henry⁶, and Caroline D Rae⁷

¹UNSW Australia, NeuRA, Sydney, Australia, ²UNSW Australia, Sydney, Australia, ³NeuRA, Sydney, Australia, ⁴Reed College, Portland, WA, United States, ⁵St. Vincent's Hospital, Sydney, Australia, ⁶UCSF, San Francisco, CA, United States, ⁷The University of New South Wales, Randwick, Australia

DTI was performed in 40 HIV- men and 82 HIV+ men with comparable demographics and life styles. The study was designed to recruit chronic HIV+ participants with successful viral control. DTI was 32 directions; FA values were quantified in each participant in 12 skeleton regions of interest, which have been associated with HIV-related brain injury. The study present first evidence for complex brain repair processes in treated and chronic HIV infection arguing for careful multilevel characterization of HIV+ samples in neuroHIV DTI studies. The association of neurocognitive function with FA suggests ongoing vulnerability despite successful treatment.

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