Abstract #4096

Reduced Creatine Concentrations in Severe Short-sleep Insomnia Disorder

Christopher B Miller¹, Caroline D Rae², Michael Green², Brendon Yee^1,3, Christopher J Gordon^1,4, Nathaniel S Marshall¹, Simon D Kyle⁵, Colin A Espie⁵, Ronald R Grunstein¹, and Delwyn J Bartlett¹

¹NeuroSleep and Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia, ²The University of New South Wales, Randwick, Australia, ³3 Department of Respiratory and Sleep Medicine, RPAH, Sydney, Australia, ⁴Sydney Nursing School, Sydney, Australia, ⁵Nuffield Department of Clinical Neurosciences and Sleep & Circadian Neuroscience Institute, The University of Oxford, Oxford, United Kingdom

We investigated 31 subjects with Insomnia Disorder grouped by hierarchical cluster analysis into long (N = 19) or short (N = 12) sleep duration insomnia and 16 healthy, good sleeping controls using an aymmetric PRESS MRS sequence at 3T in the left occipital cortex. A super metabolite variable constructed from creatine, Asp, Glu and Gln separated short sleeping insomnia from long sleeping and controls, positively correlated with total sleep duration and negatively with wake-time after sleep onset. Short sleep is associated with reduced creatine concentration.

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