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Abstract #4096

Reduced Creatine Concentrations in Severe Short-sleep Insomnia Disorder

Christopher B Miller1, Caroline D Rae2, Michael Green2, Brendon Yee1,3, Christopher J Gordon1,4, Nathaniel S Marshall1, Simon D Kyle5, Colin A Espie5, Ronald R Grunstein1, and Delwyn J Bartlett1

1NeuroSleep and Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia, 2The University of New South Wales, Randwick, Australia, 33 Department of Respiratory and Sleep Medicine, RPAH, Sydney, Australia, 4Sydney Nursing School, Sydney, Australia, 5Nuffield Department of Clinical Neurosciences and Sleep & Circadian Neuroscience Institute, The University of Oxford, Oxford, United Kingdom

We investigated 31 subjects with Insomnia Disorder grouped by hierarchical cluster analysis into long (N = 19) or short (N = 12) sleep duration insomnia and 16 healthy, good sleeping controls using an aymmetric PRESS MRS sequence at 3T in the left occipital cortex. A super metabolite variable constructed from creatine, Asp, Glu and Gln separated short sleeping insomnia from long sleeping and controls, positively correlated with total sleep duration and negatively with wake-time after sleep onset. Short sleep is associated with reduced creatine concentration.

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