Abstract #4098

Neurotoxic side effects of immunosuppressive in patients after liver transplantation: Preliminary results of a brain 31P-MRS study

Birte Schmitz¹, Anita B. Tryc², Karin Weißenborn², Henning Pflugrad², Heinrich Lanfermann¹, and Xiao-Qi Ding¹

¹Institute for Neuroradiology, Hannover Medical School, Hannover, Germany, ²Institute for Neurology, Hannover Medical School, Hannover, Germany

Patients treated with immunosuppressive calcineurin inhibitors (CNI) for at least 3 years after liver transplantation were studied by using non-localized whole brain 31P-MRS at 3T to evaluate possible chronic neurotoxic side effects of the CNI. Global concentrations of brain high-energy metabolites Adenosine-5'-triphosphate (ATP) and phosphocreatine (PCr) were estimated. The values of the patient with different doses of CNI were compared with those of age-matched healthy volunteers. In our preliminary results significant lower concentrations of ATP and PCr were found in patients treated both with standard and low doses of CNI, indicating possible neurotoxic side effects.

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