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Abstract #4101

Increased Apparent Diffusion Coefficient And Thickness In The Optic Nerve Is Associated With Visual Acuity Loss In Optic Pathway Glioma

Patrick W. Hales1, Kshitij Mankad2, Patricia O'Hare2, Victoria Smith2, Darren Hargrave2, and Christopher Clark1

1Developmental Imaging & Biophysics Section, University College London Institute of Child Health, London, United Kingdom, 2Great Ormond Street Children's Hospital, London, United Kingdom

Conventional MRI sequences have so far failed to provide imaging biomarkers that reliably differentiate asymptomatic optic pathway glioma (OPG) tumours from those which cause visual impairment. ADC maps are now acquired as standard in most institutions, and despite their typically limited resolution, may provide quantitative assessment of tumour invasion of the optic nerve. We measured ADC and optic nerve thickness using standard clinical imaging sequences in OPG patients, in conjunction with visual assessment. We found that the product of ADC and nerve thickness showed a significant correlation with visual acuity, and was significantly increased in patients who had gone blind.

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