Abstract #4101

Increased Apparent Diffusion Coefficient And Thickness In The Optic Nerve Is Associated With Visual Acuity Loss In Optic Pathway Glioma

Patrick W. Hales¹, Kshitij Mankad², Patricia O'Hare², Victoria Smith², Darren Hargrave², and Christopher Clark¹

¹Developmental Imaging & Biophysics Section, University College London Institute of Child Health, London, United Kingdom, ²Great Ormond Street Children's Hospital, London, United Kingdom

Conventional MRI sequences have so far failed to provide imaging biomarkers that reliably differentiate asymptomatic optic pathway glioma (OPG) tumours from those which cause visual impairment. ADC maps are now acquired as standard in most institutions, and despite their typically limited resolution, may provide quantitative assessment of tumour invasion of the optic nerve. We measured ADC and optic nerve thickness using standard clinical imaging sequences in OPG patients, in conjunction with visual assessment. We found that the product of ADC and nerve thickness showed a significant correlation with visual acuity, and was significantly increased in patients who had gone blind.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.