Abstract #4102

Interleaved acquisition of high resolution 3D susceptibility-weighted and FLAIR MRI

Refaat E Gabr¹, Amol S Pednekar², and Ponnada A Narayana¹

¹Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston (UTHealth), houston, TX, United States, ²Philips Healthcare, Cleveland, OH, United States

Combining the contrast of susceptibility weighted imaging (SWI) and fluid-attenuated inversion recovery (FLAIR) allows simultaneous visualization of multiple sclerosis lesions and the penetrating veins and iron deposition. However, the need for image registration, to account for patient motion between the scans, adds to the complexity of the post-processing pipeline, and introduces undesirable blurring of the image. We have developed an interleaved sequence for simultaneous acquisition of 3D FLAIR and SWI data, which produces self-registered images in a clinically feasible time, greatly simplifying the post-processing steps and eliminating interpolation effects. The interleaved time delays in between the FLAIR and SWI modules provide a degree of freedom for further optimization of the image contrast. Experiments in MS patients show the utility of the proposed sequence.

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