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Abstract #4113

The integrity and atherosclerosis of Circle of Willis detected by bright-blood and black-blood MRI are associated with severity of stroke

Le He1, Rui Li1, Xihai Zhao1, Shuo Chen1, and Huijun Chen1

1Center for BioMedical Imaging Research, Tsinghua University, Beijing, China, People's Republic of

Circle of Willis (CoW) is an important source of collateral blood flow, which may influence the severity of ischemia stroke. However, traditional methods only evaluate the luminal conditions of CoW. This study evaluate the luminal and vessel wall conditions of CoW using bright- and black-blood MRI. We found that most stroke patients have incomplete CoW, and patients with atherosclerotic CoW tends to have larger ischemic infraction. More importantly, the infarction size in stroke patients was significantly associated with integrity&atherosclerosis of CoW, suggesting that the integrity and atherosclerosis of CoW may be a risk factor for stroke severity.

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