Abstract #4114

Characterization of Asymptomatic Intracranial Atherosclerosis using 3D High Resolution Contrast-enhanced MRI

Huan Yang^1,2, Xuefeng Zhang^1,3, Li Liu¹, Qing Hao⁴, Victor Urrutia⁴, Qin Qin^1,5, Bruce A. Wasserman¹, and Ye Qiao¹

¹The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD, United States, ²Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, People's Republic of, ³Inner Mongolia Autonomous Region People's Hospital, Inner Mongolia, China, People's Republic of, ⁴Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Although most of strokes occur in asymptomatic patients, most studies have been conducted in symptomatic cohort. Here we aimed to characterize ICAD in stroke-free participants and compare with stroke patients using 3D high-resolution contrast-enhanced BBMRI. Nineteen asymptomatic and 15 stroke patients were included and underwent a standardized protocol which contains 3D TOF MRA and pre- and post-contrast 3D BBMRI imaging. Plaque enhancement was categorized, and morphology and signal-based measurements were compared. The results showed that asymptomatic plaques demonstrated lower contrast-enhancement compared with symptomatic plaques. Contrast-enhancement of ICAD may serve as a marker for plaque stability, providing insight into stroke risk.

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