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Abstract #4128

Microstructural alterations detected by dMRI in KO mouse model showing schizophrenic like phenotype

Nicolas Kunz1, Alexandre Bacq2, Jocelin Grosse2, Rolf Gruetter1,3, and Carmen Sandi2

1CIBM-AIT, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland, 2Laboratory of Behavioral Genetics, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland, 3Department of Radiology, University of Geneva and Lausanne, Geneva, Lausanne, Switzerland

Schizophrenia is a severe mental disorder that afflicts 1% of the world’s population. However, the cause of this disorder remains unknown. Increasing evidence points toward a neurodevelopmental mechanism, which implicates genes involved in neuronal proliferation, migration, or synapse formation. We investigate microstructural changes by ex-vivo diffusion MRI in PSA-KO mice brain. Trends of microstructural alterations were visible in a few fiber tracts such as ST, ST-post, AC and FX. These preliminary results suggest that altered plasticity during development of the PSA-KO mice, presenting schizophrenic like phenotype and altered sociability, creates long term effects and structural alterations depicted by dMRI.

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