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Abstract #4127

Glutamatergic metabolism and disease severity in Schizophrenia: a 7T MRS study

Subechhya Pradhan1, Laura M. Rowland2, S. Andrea Wijtenburg2, Stephanie Korenic2, Sarah Nosinger2, L. Elliot Hong2, and Peter B. Barker1,3

1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States, 3Radiology, Kennedy Krieger Institute, Baltimore, MD, United States

Imbalance in the glutamatergic system is implicated in the pathophysiology of schizophrenia. Various previous MRS studies have reported altered levels of glutamate and/or glutamine in schizophrenia, however most of these studies have been performed at 3T or lower where separation from Glu from Gln is challenging, and few have looked at correlations with disease severity or cognitive impairment. The purpose of this study was to investigate neurochemical differences in participants with and without schizophrenia using high-resolution 7T MRS in multiple brain regions, and to exam correlations with measures of cognitive impairment, function and symptom severity.

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