Abstract #4130

31P MRS study of schizophrenia induced changes of energy metabolism in activated cerebral cortex.

Andrei Valerievich Manzhurtsev¹, Maxim Vadimovich Ublinskii^1,2, Irina Sergeevna Lebedeva³, Tolibjon Abdullaevich Akhadov², Petr Evgenevich Menshchikov⁴, and Natalia Alexandrovna Semenova^1,2,4

¹Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russian Federation, ²Radiology, Scientific Research Institute of Children's Emergent Surgery and Trauma, Moscow, Russian Federation, ³Scientific Centre of Mental Health, Moscow, Russian Federation, ⁴Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russian Federation

³¹P MRS in the period of neuroactivation allows direct analysis of metabolic response on energy consuming processes. In this study we revealed decreased creatine kinase system response in visual cortex of early stage schizophrenia patients in the period of videostimulation: while PCr in normal activated cortex is reduced for ATP regeneration during activation, no PCr decrease was observed in patients. The data obtained allowed to offer a new neuronal metabolism scheme in response to stimulation at early stage of schizophrenia.

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