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Abstract #4131

A novel framework for global comparison of tract-topology between subjects reveals callosum shape variations in first episode psychosis

Greg D Parker1, George J.A. Evans2, and Derek K Jones1,3

1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2School of Medicine, Newcastle University, Newcastle, United Kingdom, 3Neuroscience and Mental Health Research Institute (NMHRI), School of Medicine, Cardiff University, Cardiff, United Kingdom

Changes in the size and shape of white matter tracts are known to be associated with the onset or progress of various brain disorders. Common techniques for characterising tract shape include measuring cross sectional area or thickness1-3, Fourier descriptors4 and measures of streamline dispersion5. Here we present a novel principal component analysis (PCA)-based method and demonstrate two ways in which those representations may be used to examine inter-group differences in tract shape. As an example, we compare 30 first-episode psychosis patients with age/sex matched controls and find significant shape differences in the genu of the callosum.

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