Abstract #4132

Common Pattern of Gray Matter Changes in First Episode Schizophrenia Patients with and without Antipsychotics: VBM Meta-analyses Using Signed Differential Mapping

Chandan Shah¹, Wenjing Zhang¹, Yuan Xiao², Li Yao², Xin Gao², Lu Liu², Jieke Liu², Siyi Li², Qiyong Gong², and Su Lui²

¹Radiology, Sichuan University, Chengdu, China, People's Republic of, ²Chengdu, China, People's Republic of

Current study provides an insight about the brain morphological changes of first episode schizophrenia patients at drug-naive state and after antipsychotic treatment. Our study reveals that GM changes in frontal, temporal and insular regions are the fundamental regions of pathologic GM changes in first-episode schizophrenia irrespective of antipsychotic medication. This common pattern of GM changes in first episode schizophrenia patients with and without antipsychotics suggest the anatomical deficits involved in the fronto-temporal and limbic regions are likely to be the trait- instead of state-related changes at the early course of illness in schizophrenia. Until now only assumptions have been made about the potential effects of antipsychotics rather than making a strong statement due to lack of proper investigation methods and also due to difficulty in gaining access to a satisfactory number of drug naïve and medicated patients group of the same age. We therefore hope this study would be helpful in providing important information about the pathology of the schizophrenic brain after the early course of treatment with antipsychotics.

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