Abstract #4134

A 7T MRS Study of First Episode Psychosis: glutamatergic abnormalities and correlations with symptom severity

Subechhya Pradhan¹, Anouk Marsman¹, Rebecca Ward², Candice Ford², Ashley Lloyd², David Schretlen^1,2, Akira Sawa², and Peter B. Barker^1,3

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiology, Kennedy Krieger Institute, Baltimore, MD, United States

Imbalance in glutamatergic systems is implicated in the pathophysiology of psychosis. The purpose of this study was to assess differences in metabolite levels between subjects with a first episode of psychosis (FEP) and healthy controls, and to study correlations between metabolites and measures of disease severity, including neuropsychological scales, positive and negative symptoms.

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