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Abstract #4135

Glutamatergic metabolite concentrations in the superior temporal gyrus in schizophrenia are increased and glutamate predicts neuroticism

Florian Schubert1, Ralf Mekle1, Johanna Balz2, Julian Keil2, Yadira Roa Romero2, Bernd Ittermann1, Jürgen Gallinat3, and Daniel Senkowski2

1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Findings of deviant glutamate (Glu) and glutamine (Gln) levels in brain of patients support the glutamate hypothesis of schizophrenia. Thickness and volume of the left superior temporal gyrus (STG) are established endophenotypes of schizophrenia. We quantified glutamatergic metabolites using proton MRS with SPECIAL in the left STG of schizophrenic patients and controls, and investigated the relationships between Glu and personality traits. Glu was significantly higher in patients than in controls, Gln likewise but with a weak trend only. Glu predicted neuroticism in patients. Our results suggest dysfunctional glutamatergic neurotransmission in STG and confirm widespread Glu increases in cortical regions in schizophrenia.

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