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Abstract #4136

Cortical GluCEST in Schizophrenia and Youth at Clinical High Risk for Psychosis

Ravi Prakash Reddy Nanga1, David R. Roalf2, Petra Rupert2, Megan Quarmley2, Hari Hariharan1, Mark Elliott1, Raquel E. Gur2, Paul J. Moberg2, Ravinder Reddy1, and Bruce I. Turetsky2

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

In this glutamate Chemical Exchange Saturation Transfer (GluCEST) study, typically developing individuals and youth at clinical high risk for psychosis exhibit subtle, but significant, abnormalities in brain glutamate, similar to patients with schizophrenia in the entire cortical area. GluCEST technique holds distinct promise for understanding neurodevelopmental contributions to schizophrenia pathophysiology.

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