Abstract #4136

Cortical GluCEST in Schizophrenia and Youth at Clinical High Risk for Psychosis

Ravi Prakash Reddy Nanga¹, David R. Roalf², Petra Rupert², Megan Quarmley², Hari Hariharan¹, Mark Elliott¹, Raquel E. Gur², Paul J. Moberg², Ravinder Reddy¹, and Bruce I. Turetsky²

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

In this glutamate Chemical Exchange Saturation Transfer (GluCEST) study, typically developing individuals and youth at clinical high risk for psychosis exhibit subtle, but significant, abnormalities in brain glutamate, similar to patients with schizophrenia in the entire cortical area. GluCEST technique holds distinct promise for understanding neurodevelopmental contributions to schizophrenia pathophysiology.

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