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Abstract #4143

One-Class Classifiers detect a specific endophenotype in young children with Autism Spectrum Disorders

Alessandra Retico1, Ilaria Gori1,2, Alessia Giuliano1,3, Piernicola Oliva1,2, Michela Tosetti4, Filippo Muratori3,4, and Sara Calderoni4

1National Institute of Nuclear Physics, Pisa, Italy, 2University of Sassari, Sassari, Italy, 3University of Pisa, Pisa, Italy, 4IRCCS Stella Maris Foundation, Pisa, Italy

Binary classifiers are widely used to analyze brain MRI features and to identify useful biomarkers of pathology. Strong challenges arise when dealing with extremely heterogeneous conditions such as Autism Spectrum Disorders (ASD). We propose the use of the One-Class Classifier (OCC) method that, in contrast to two-class classification, is based on the description of the positive class only. A test of similarity of new cases to the positive examples is then performed, and they are eventually considered as outliers. The application of OCC to Freesurfer-based brain MRI features identified a specific endophenotype in young children with ASD.

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