Abstract #4144

Identification of Novel Gene-Specific Bioimaging Markers in Autism Spectrum Disorder

Judith A. Gadde¹ and John-Paul J. Yu^1,2

¹Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ²Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

Autism spectrum disorder (ASD) is a complex genetic neurodevelopmental disorder. Differential expression patterns, splice-variants, and mutations in Neurexin1 (Nrxn1) have been implicated in the neurodevelopment of ASD. New targeted genome editing technologies have yielded the first cogent genetic animal models of ASD with animals harboring biallelic deletions of Nrxn1, allowing for the assessment of gene-specific perturbations in white matter composition and organization. Interrogating changes in brain structure attributable to a specific genetic allele is the first step towards the development and validation of an objective imaging biomarker, which can contribute to the diagnosis of ASD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.