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Abstract #4145

Abnormal brain structure is associated with depression and anxiety in obese patients using DTI

Yi-Chun Liu1, Vincent Chin-Hung Chen2, Hse-Huang Chao3, Ming-Chou Ho4, and Jun-Cheng Weng1,5

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 3Tiawan Center for Metabolic and Bariatric Surgery, Jen-Ai Hospital, Taichung, Taiwan, 4Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, 5Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Since there is more and more delicious food in our daily life, people cannot resist the attraction to food. Therefore, obesity has become an important issue in modern society. Previous studies used food pictures to stimulate obese patients and used functional MRI to find the brain regions with increased activity. However, few studies mentioned about particular brain structure changes in obese patient. Noninvasive diffusion tensor imaging (DTI) are able to observe the water diffusion in the brain on the microscopic level for the early detection of white matter structural changes. Therefore, we used DTI to find the differences of brain structures between obese patients and healthy controls. The correlation between clinical and the DTI indices were also calculated and discussed. The clinical indices included body mass index (BMI), and measures of anxiety and depression.

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