Abstract #4146

Mapping Cerebral Oxidative Metabolism of Oxygen in Patients with Post-Stroke Apathy

Xiang He¹, Kenneth Wengler^1,2, Ananth Narayanan³, Chuan Huang¹, Christine DeLorenzo³, Ramin Parsey³, Mark Schweitzer¹, and Andrew Goldfine³

¹Radiology, Stony Brook University School of Medicine, Stony Brook, NY, United States, ²Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ³Psychiatry, Stony Brook University School of Medicine, Stony Brook, NY, United States

Five post-stroke apathy patients underwent simultaneous ¹⁸F-FDG-PET/MRI to determine brain metabolic rates. PET data was used to determine whole brain metabolic rate of glucose (MR_Glu). Quantitative BOLD and arterial spin labeling MRI was used to determine cerebral metabolic rate of oxygen (CMRO₂). Metabolic rates were compared for the two modalities to determine useful information associated with post-stroke apathy. The prefrontal cortex showed decreased metabolic rates for both CMRO₂ and MR_Glu potentially indicating apathy. MR qBOLD-derived CMRO₂ measurements demonstrated good correlation with PET ¹⁸F-FDG metabolism, providing strong support for its adoption as a non-invasive mapping of brain metabolism in patients with post-stroke apathy.

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