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Abstract #4146

Mapping Cerebral Oxidative Metabolism of Oxygen in Patients with Post-Stroke Apathy

Xiang He1, Kenneth Wengler1,2, Ananth Narayanan3, Chuan Huang1, Christine DeLorenzo3, Ramin Parsey3, Mark Schweitzer1, and Andrew Goldfine3

1Radiology, Stony Brook University School of Medicine, Stony Brook, NY, United States, 2Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 3Psychiatry, Stony Brook University School of Medicine, Stony Brook, NY, United States

Five post-stroke apathy patients underwent simultaneous 18F-FDG-PET/MRI to determine brain metabolic rates. PET data was used to determine whole brain metabolic rate of glucose (MRGlu). Quantitative BOLD and arterial spin labeling MRI was used to determine cerebral metabolic rate of oxygen (CMRO2). Metabolic rates were compared for the two modalities to determine useful information associated with post-stroke apathy. The prefrontal cortex showed decreased metabolic rates for both CMRO2 and MRGlu potentially indicating apathy. MR qBOLD-derived CMRO2 measurements demonstrated good correlation with PET 18F-FDG metabolism, providing strong support for its adoption as a non-invasive mapping of brain metabolism in patients with post-stroke apathy.

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