Abstract #4148

Abnormal brain volume and shape are associated with aspects of inhibitory control and implicit attitude toward betel nut in chewers

Deborah Xiu-Ning Lin¹, Shu-Wei Chu¹, Ming-Chou Ho², and Jun-Cheng Weng^1,3

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, ³Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Betel nut is the seed of the betel palm, which grows in the tropical or subtropical regions, especially in Taiwan, India, China and parts of east Africa. It has been confirmed that chewing betel nuts can be addicted to it and is also carcinogenic to humans. Chewing betel nuts lead to a greatly increased risk of developing a range of serious diseases, including oral and esophagus cancers. In Taiwan, 88% of people who were diagnosed to oral cancer have the habit of chewing betel nuts, but very few researches studied on how chewing betel nuts effects brian structure. Therefore, in this study we tried to find out the structural volume and shape changes in the brain between betel nut chewers and healthy controls with voxel-based morphometry (VBM) and vertex-wise shape analyses. In addition, the relationship between brain structural volume size and implicit attitude or inhibitory control were also discussed.

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