Abstract #4149

Glutamate level change in anterior cingulate elicited by alcohol cues in alcohol use disorder

Hu Cheng¹, Derek Kellar¹, Ulrike Dydak^2,3, Peter Finn¹, Allison Lake ¹, Shalmali Dharmadhikari^2,3, George Rebec ¹, and Sharlene Newman¹

¹Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States, ²School of Health Sciences, Purdue University, West Lafayette, IN, United States, ³Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Evidence indicates that glutamate neurotransmission plays a critical role in alcohol and other substance addiction. This study investigated the dynamic change of glutamate level elicited by alcohol cues in individuals with alcohol use disorder (AUD). Both the absolute value of glutamate concentration and its ratio to total creatine measured decreased significantly for AUD subjects after they viewed the pictures of alcoholic beverages. A high correlation (r = -0.90) between baseline glutamate level and alcohol problem counts was observed for AUD subjects. This cue induced decrease of glutamate is not a direct translation from animal studies.

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