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Abstract #4150

Disadvantage of social sensitivity: Interaction of oxytocin receptor genotype (OXTR rs53576) and childhood maltreatment on limbic gray matter

Harald Kugel1, Udo Dannlowski2,3, Dominik Grotegerd2, Ronny Redlich2, Nils Opel 2, Katharina Dohm2, Dario Zaremba2, Anne Groegler2, Juliane Schwieren2, Thomas Suslow4, Patricia Ohrmann 2, Jochen Bauer1,2, Axel Krug3, Tilo Kircher3, Christa Hohoff2, Katharina Domschke5, Andreas Jansen3, Pienie Zwitserlood6, Markus Heinrichs7,8, Volker Arolt2, Walter Heindel1, and Bernhard T. Baune9

1Department of Clinical Radiology, University of Muenster, Muenster, Germany, 2Department of Psychiatry, University of Muenster, Muenster, Germany, 3Department of Psychiatry, University of Marburg, Marburg, Germany, 4Department of Psychosomatics and Psychotherapy, University of Leipzig, Leipzig, Germany, 5Department of Psychiatry, University of Wuerzburg, Wuerzburg, Germany, 6Department of Psychology, University of Muenster, Muenster, Germany, 7Department of Psychology, University of Freiburg, Freiburg, Germany, 8Freiburg Brain Imaging Center, University of Freiburg, Freiburg, Germany, 9School of Medicine, Discipline of Psychiatry, University of Adelaide, Adelaide, Australia

Oxytocin is a pro-social and anxiolytic neuropeptide, especially if the G-allele of a common polymorphism (rs53576) in the oxytocin receptor gene is present. Recent studies suggest, however, a detrimental role of this allele in the context of childhood maltreatment. Structural MRI data show reduced gray matter volumes of the ventral striatum, fMRI shows increased amygdala responsiveness associated with increased CTQ (maltreatment) score. Thus for individuals with adverse childhood experiences the G-allele may be a vulnerability factor.

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