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Abstract #4152

Alteration of white matter microstructure within the reward circuit revealed by neurite orientation dispersion and density imaging (NODDI)

Kouhei Kamiya1, Naohiro Okada2, Yuichi Suzuki3, Ryusuke Irie1, Takatoshi Kubo1, Yudai Nakai4, Yasumasa Nippashi1, Daisuke Koshiyama2, Kentaro Morita2, Kingo Sawada2, Yoshihiro Satomura2, Shinsuke Koike2,5, Harushi Mori1, Akira Kunimatsu1, Kiyoto Kasai2, and Kuni Ohtomo1

1The Department of Radiology, The University of Tokyo, Tokyo, Japan, 2The Department of Neuropsychiatry, The University of Tokyo, Tokyo, Japan, 3The Department of Radiological Technology, The University of Tokyo Hospital, Tokyo, Japan, 4The Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan, 5Office for Mental Health Support, Division for Counseling and Support, The University of Tokyo, Tokyo, Japan

This study aimed to investigate the brain microstructural alteration in patients with major depressive disorder (MDD) using neurite orientation dispersion and density imaging (NODDI). Nineteen MDD patients and 13 controls were involved. The TBSS analyses revealed significant increase in orientation dispersion index (ODI) in patients with MDD, distributed in bilateral frontal lobes and right occipital lobe, right internal capsule, bilateral thalamus and hypothalamus, right nucleus accumbens, and midbrain tegmentum, suggesting involvement of the reward circuit. The neurite density was not significantly altered, arousing interest on further study focusing on treatment response, whether the ODI increase is reversible or not.

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