Abstract #4153

Alterations of neural correlates in drug-naïve first episode pediatric patients with posttraumatic stress disorder: An optimized voxel-based morphometry study

Lei Li¹, Xinyu Hu¹, Du Lei¹, Xiaoqi Huang¹, and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of

The current study used voxel-based morphometry (VBM)-diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) algorithm to investigate the gray matter abnormalities in drug-naïve first-episode pediatric patients with posttraumatic stress disorder (PTSD) using high resolution structural MRI. Meanwhile, we investigated the association between altered neural correlates and symptom severity as measured by clinician-administered PTSD scale (CAPS) and PTSD checklist (PCL) scores with the age as a covariate. The current study provided the preliminary evidence that the intrinsic abnormalities of neural correlates in pediatric PTSD patients were mainly in fear circuit and default mode network.

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