Abstract #4154

Altered whole brain functional connectivity in drug-naive patients with obsessive–compulsive disorder: A resting-state functional magnetic resonance imaging study

Xinyu Hu¹, Xi Yang², Yanchun Yang², Qiyong Gong¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ²Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, People's Republic of

We analysis whole brain connectivity in a relatively large sample of drug-naive patients with obsessive-compulsive disorder (OCD) using a novel graph-theory approach known as functional connectivity strength (FCS) to identify brain regions displaying high-degree centrality of connectivity. Based on the new approach of FCS, our findings demonstrated obvious significant hyperactivity of default mode network (DMN) in OCD patients at resting state. Furthermore, our results provided evidence that besides the prevailing model of cortical–striatal–thalamic–cortical circuits in OCD, the disequilibrium between the DMN and the salience network (SN) might be associated with the pathophysiology of OCD.

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