Abstract #4155

Altered Intrinsic Brain Functional Connectivity in Suicidal Patients with Major Depressive Disorder

Ziqi Chen¹, Mingrui Xia², Jia Liu¹, Zhiyun Jia^1,3, Xin Xu^1,4, Weihong Kuang⁴, Yong He², and Qiyong Gong^1,5

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ²State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, People's Republic of, ³Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ⁴Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ⁵Department of Psychology, School of Public Administration, Sichuan University, Chengdu, China, People's Republic of

The underlying neural correlates of suicide attempts in major depressive disorder (MDD) at the connectivity or circuit level remains incompletely understood. Therefore, we utilized a graph-theory approach—functional connectivity strength (FCS) to identify resting-state functional connectivity alterations of whole-brain networks in MDD patients with a history of suicide attempts. Relative to healthy controls, two MDD patient groups (attempters and non-attempters) showed overlapping reduced FCS in the middle and inferior occipital gyrus (IOG), insula, superior temporal gyrus, thalamus and limbic regions, while attempters showed more decreased FCS in right insula and left IOG. The depression severity was positively correlated with FCS in right thalamus in suicide attempters. Disconnection of the insula and IOG could be biological correlates of impaired decision making and emotional information processing in MDD patients with a history of suicide attempt.

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