Abstract #4156

Functional connectivity and neuroanatomical differences in a stress susceptible and resilient mouse model

Victoria X Wang¹, Caroline Menard², Cheuk Ying Tang³, Frances Marks¹, Johnny C Ng¹, Lazar Fleysher¹, Zahi A Fayad¹, and Scott Russo²

¹Radiology, Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, United States, ²Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Radiology & Psychiatry, Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, United States

We studied functional and structural connectivity in a stress susceptible and resilient mouse model using rsfMRI and DTI. We also investigated the integrity of the Blood Brain Barrier using Gd-DTPA. We found hyperactivity in the susceptible mice which had also several regions in the brain with compromised BBB. We also detected increased structural connectivity in the resilient mice.

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