Altered Dynamic Functional Connectivity of Amygdala in Major Depressive Disorder
Lihua Qiu1,2, Mingrui Xia3, Yong He3, and Qiyong Gong2
1Radiology, The Second People's Hospital of Yibin, Yibin, China, People's Republic of, 2West China Hospital of Sichuan University, Chengdu, China, People's Republic of, 3Beijing Normal University, Beijing, China, People's Republic of
Neuroimaging
studies have shown that MDD is accompanied by functional abnormalities in
amygdala and related connections; yet, little is known about amygdala subregion
dynamic functional connectivity alterations of the whole-brain networks in MDD
patients. In this work, general linear model analysis were
used to assess the between-group differences of amygdalar subregion dynamic functional connectivity
alterations in MDD patients. We found the altered amygdaloid projection
were mainly in brainstem, cerebellum, thalamus, temporal and orbital cortical
areas. These areas belong to limbic-thalamo-cortical circuitry which play
important role in MDD and may associated with the impaired emotional modulation
ability in MDD.
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