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Abstract #4157

Altered Dynamic Functional Connectivity of Amygdala in Major Depressive Disorder

Lihua Qiu1,2, Mingrui Xia3, Yong He3, and Qiyong Gong2

1Radiology, The Second People's Hospital of Yibin, Yibin, China, People's Republic of, 2West China Hospital of Sichuan University, Chengdu, China, People's Republic of, 3Beijing Normal University, Beijing, China, People's Republic of

Neuroimaging studies have shown that MDD is accompanied by functional abnormalities in amygdala and related connections; yet, little is known about amygdala subregion dynamic functional connectivity alterations of the whole-brain networks in MDD patients. In this work, general linear model analysis were used to assess the between-group differences of amygdalar subregion dynamic functional connectivity alterations in MDD patients. We found the altered amygdaloid projection were mainly in brainstem, cerebellum, thalamus, temporal and orbital cortical areas. These areas belong to limbic-thalamo-cortical circuitry which play important role in MDD and may associated with the impaired emotional modulation ability in MDD.

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