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Abstract #4158

Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder

Andreas Hock1,2, Jutta Ernst2, Anke Henning1,3, Erich Seifritz2, Heinz Boeker2, and Simone Grimm2,4

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 4Department of Psychiatry, Charité, Berlin, Germany

Proton magnetic resonance spectroscopy (1H-MRS) was used to test whether patients with major depressive disorder have increased glucose and lactate levels in the pregenual anterior cingulate cortex (PACC) compared to healthy controls. Therefore, forty healthy and depressed participants spectra were acquired from the PACC using a maximum echo JPRESS protocol. Results show significant increases of glucose and lactate in patients, which are also associated with depression severity. These findings indicate impaired brain energy metabolism in MDD with increased fraction of energy utilization via glycolysis and reduced mitochondrial oxidative clearance of lactate.

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