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Abstract #4159

Increase of grey matter following bifrontal rTMS in drug resistant major depressive disorder patients: A VBM study

Elisa Kallioniemi1,2, Mervi Könönen1,3, Juhana Hakumäki3, Esa Mervaala1, Heimo Viinamäki4, Ritva Vanninen3, and Minna Valkonen-Korhonen4

1Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland, 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 3Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland, 4Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland

Repetitive transcranial magnetic stimulation (rTMS) is able to induce long-term excitatory and inhibitory effects on cortical functions if applied repeatedly over several days. Thus, rTMS possesses a great potential in therapeutic applications and several promising therapies have already been developed. Whether rTMS causes structural neuroplasticity, however, remains mainly unknown. In this study, we found that bifrontal rTMS applied to dorsolateral prefrontal cortex (DLPFC) elicited structural changes in major depressive disorder patients. The increase in grey matter was found in the right post- and precentral gyri, which are both functionally connected to DLPFC.

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