Abstract #4162

White matter microstructure is associated with auditory and tactile processing in children with and without sensory processing disorder

Yi-Shin Chang¹, Mathilde Gratiot¹, Julia Owen¹, Anne Brandes-Aitken¹, Shivani Desai¹, Susanna Hill¹, Anne Arnett¹, Julia Harris¹, Elysa Marco¹, and Pratik Mukherjee¹

¹University of California in San Francisco, San Francisco, CA, United States

Sensory processing disorders (SPD) affect 5-16% of school-aged children, and can cause downstream deficits of intellectual and social development. In this study, we use diffusion tensor imaging to study a cohort of 41 children with SPD and 41 typically developing children ages 8-12. We confirm and generalize results from our prior pilot study indicating disrupted posterior white matter in SPD, and further demonstrate a relationship between direct measurements of tactile and non-linguistic auditory function and white matter microstructure -- not just in SPD, but also in typically developing children.

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