Abstract #4163

Intra-hippocampal Diffusion Tensor Imaging Identifies Dendritic Abnormalities After Early-life Stress

Jenny Molet¹, Pamela M Maras¹, Eli Kinney-Lang^1,2, Fasial Rashid², Neil Harris³, Autumn Ivy¹, Ana Solodkin^1,4, Tallie Z Baram^1,5, and Andre Obenaus^2,5

¹Anatomy/Neurobiology, University of California, Irvine, Irvine, CA, United States, ²Pediatrics, Loma Linda University, Loma Linda, CA, United States, ³Neurosugery, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Neurology, University of California, Irvine, Irvine, CA, United States, ⁵Pediatrics, University of California, Irvine, Irvine, CA, United States

The effects of early-life adversity observed in the brain anatomy of rodents might be instructive about the human condition. Chronic early life stress in a rodent model results in dendritic paring in the dorsal hippocampus. High resolution volumetric MRI found hippocampal volume loss and DTI measures of microstructure found increased fractional anisotropy. Structural MRI measures can be used to find microstructural abnormalities related to dendritic morphological abnormalities. Thus, MRI metrics could be subsequently tested clinically to monitor adolescents at risk for neuropsychiatric illness.

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