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Abstract #4163

Intra-hippocampal Diffusion Tensor Imaging Identifies Dendritic Abnormalities After Early-life Stress

Jenny Molet1, Pamela M Maras1, Eli Kinney-Lang1,2, Fasial Rashid2, Neil Harris3, Autumn Ivy1, Ana Solodkin1,4, Tallie Z Baram1,5, and Andre Obenaus2,5

1Anatomy/Neurobiology, University of California, Irvine, Irvine, CA, United States, 2Pediatrics, Loma Linda University, Loma Linda, CA, United States, 3Neurosugery, University of California, Los Angeles, Los Angeles, CA, United States, 4Neurology, University of California, Irvine, Irvine, CA, United States, 5Pediatrics, University of California, Irvine, Irvine, CA, United States

The effects of early-life adversity observed in the brain anatomy of rodents might be instructive about the human condition. Chronic early life stress in a rodent model results in dendritic paring in the dorsal hippocampus. High resolution volumetric MRI found hippocampal volume loss and DTI measures of microstructure found increased fractional anisotropy. Structural MRI measures can be used to find microstructural abnormalities related to dendritic morphological abnormalities. Thus, MRI metrics could be subsequently tested clinically to monitor adolescents at risk for neuropsychiatric illness.

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